The desire to correct wrinkles or increase the volume of cheekbones, lips, as well as, breasts, gluteus, among others; Has led laboratories (with investments of hundreds of millions of euros), to produce more than 40 injectable fillers.

Each of these substances have been used to disguise age or improve certain facial and body features.

Many physicians place substances without being properly trained, or using products that are not biocompatible or suitable for these procedures. However, when there is some complication, very few know and are dedicated to remove them.

That is why in Clinica Sanza we saw the need to inform our patients of these types of complications called “iatrogenic alogenosis” which can be avoided and treated by specialists dedicated to it like Dr. Ignacio Sanza and his team.

What is Iatrogenic Alogenosis?

The term “iatrogenic alogenosis” has been designated to describe a disease that is produced by allogeneic substances,that is, foreign to the organism; And produced by the doctors or the people who have injected them. Among these people are “cosmetologists” or “aesthetic physicians” who do not know the real danger of what they do.

This is a disease of recent onset. However, it has a history that goes much further back, when in 1899, a doctor decided to inject paraffin into the scrotum of a child who had a testicular tuberculosis removed, the purpose was to simulate the missing testicle.

Substances from mineral and vegetable oils, solid and liquid petrolates and other paraffins, were further developed over the following years. But it is not until 1920 that the first publications of health problems are known, such as: pulmonary embolism, granulomas, skin tumors, deformities, among others.

According to a study carried out in Colombia by Dr. Helen Amelia Sanz-Barriga, 358 cases of iatrogenic allogenosis have been reported in the last 10 years for every 1000 patients using biopolymers, of which 97% are women.

This results in a large number of patients who must be treated by those who, first, should have performed the procedures; plastic surgeons with experience and knowledge in the field.

Of all these, the best known is liquid silicone or biopolymers.

Biopolymers (Liquid Silicone)

Also called “tissue implants” or “expandable cell implants”, they are substances of different origins, some are derived from petroleum, others are of vegetable origin and many are of synthetic origin such as liquid silicone.

Risks of biopolymers

Biopolymers can be dangerous mainly for 3 reasons:

  • They can trigger an excessive inflammatory reaction in the organism because they are identified as a foreign object and an autoimmune reaction is triggered.
  • They can migrate from where they were infiltrated creating distant complications.
  • Most of the time they have no sanitary control, which increases the risk of complications and side effects from infection.

Symptoms and signs

These range from general symptoms such as: pain, fever, decay, joint pain, malaise and depression. And local signs such as: inflammation, irregularities in the skin, edema, erythema, keloid scars, hyper or hypopigmentations, ulcerations, hardening, necrosis and fistulas.

Safe Alternatives to Biopolymers

There are biocompatible substances that can be used safely.

Collagen, which is a set of proteins composed of three chains of polypeptides, each containing one thousand amino acids. It can be extracted from the patient’s own skin and cultivated.

Hyaluronic acid, found in the connective tissue of mammals and in the extracellular space, is also used as filler.

Self fat, can be extracted by means of liposuction, be processed and re-injected safely as filler.

Prostheses or silicone implants for breast augmentation or buttocks are currently wrapped in a layer that insulates them from the body. They are also made of cohesive silicone gel, a type of silicone that by its texture limits and precludes the migration of the silicone. Silicone prostheses used in surgery are safe, unlike injectable biopolymers. Example: breast reconstruction after breast cancer or preventive mastectomy.

Iatrogenic alogenosis treatment

Finally we will discuss the treatment for people who currently suffer from the complications of iatrogenic alogenosis.

The treatment is fundamentally based on two things:

  1. The control of symptoms, such as inflammation, by means of analgesics, antihistamines and non-steroidal anti-inflammatory drugs.
  2. The immediate extraction of substances. Removal of these products causing deformities in the lips and other parts of the body is possible on an outpatient basis with local anesthesia or sedation and the results are very rewarding.

Because the silicone extraction surgery is complex and very different in each case, it is difficult to talk about a surgical technique and it would be difficult to understand because most patients believe that they will run out of lips or very thin or with visible face scars, and this is not so.

We will show some cases of before and after and if you have any problems, we advise you to go with Dr. Sanza or his department of extraction of biopolymers at Clinica Sanza and we will attend you with the affection and knowledge that we have of this pathology.

As a general recommendation, we advise you Always be a specialist in plastic surgery who performs any type of cosmetic treatment that involves injecting or introducing any type of substance in your body, to avoid iatrogenic alogenosis. If you currently have this problem, feel free that there are alternatives to help you in most of the cases.


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